Neoplasma Vol.53, p.19-25, 2006
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| Title: Current trends and perspectives in nutrition and cancer prevention
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| Author: I., BARTA
; P., SMERAK
; Z., POLIVKOVA
; H., SESTAKOVA
; M., LANGOVA
; B., TUREK
; J., BARTOVA
; |
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Abstract: There is an increasing evidence that dietary phytochemicals may
play important roles as chemopreventive or
chemotherapeutic agents in prevention of many diseases, including
tumors. The purpose of this study was to examine
antimutagenic effects and effect on the immune response of
representative series of substances which commonly occur in
human diet.
Using the Ames bacterial mutagenicity test and in vivo
chemiluminescence test, we investigated antigenotoxic and
immunomodulatory effects of juices and vegetable homogenates
(carrot + cauliflower, cauliflower, red cabbage, broccoli,
onion, garlic) on the genotoxicity of AFB1 and pyrolysates of
aminoacids. Using the Ames test and in vivo micronucleus, the
chemiluminescence test, the blastic transformation test and the
comet assay we examined antimutagenic effects of chemically
identified chemoprotective substances in the pure form
(resveratrol, diallylsulphide, phenethyl isothiocyanate, ellagic
acid, epigallocatechin gallate, genistein and curcumine) on
mutagenicity induced by three reference mutagens: aflatoxin B1
(AFB1), 2-amino-3-metylimidazo[4,5,-f] chinolin (IQ) and N-nitroso-
N-metylurea (MNU) and effect of phytochemicals on
the immunosuppression caused by these mutagens.
All complete vegetable homogenates and substances of plant origin
tested, showed a clear antimutagenic and
immunomodulatory activities on mutagenicity and immunosuppression
induced by reference mutagens. Only in the Ames
test the effect of some phytochemicals against direct
mutagenMNUwas lower compared to indirect mutagens AFB1 and IQ.
Similarly, resveratrol and epigallocatechin gallate had no
inhibitory effect on mutagenicity MNU in the Ames test.
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| Keywords: phytochemicals, antimutagenic effects, effect on the immune
response, Ames test, micronucleus test, chemiluminescence
and blastic transformation tests
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| Year: 2006, Volume: 53, Issue: |
Page From: 19, Page To: 25 |
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