Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.57, No.3, p.264-269, 2010 |
||
Title: MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients | ||
Author: O. Slaby, R. Lakomy, P. Fadrus, R. Hrstka, L. Kren, E. Lzicarova, M. Smrcka, M. Svoboda, H. Dolezalova, J. Novakova, D. Valik, R. Vyzula, J. Michalek | ||
Abstract: MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies showed altered expression levels of several microRNAs in glioblastomas. In this study, we examined the expression levels of selected microRNAs in 22 primary glioblastomas and six specimens of adult brain tissue by real-time PCR method. In addition, we examined methylation status of MGMT promoter by methylation-specific real-time PCR, as this has been shown to be a predictive marker in glioblastomas. MGMT methylation status was not correlated with response to concomitant chemoradiotherapy with temozolomide (RT/TMZ). MiR-221 (p=0,016), miR-222 (p=0,038), miR-181b (p=0,036), miR-181c (p=0,043) and miR-128a (p=0,001) were significantly down-regulated in glioblastomas. The most significant change was observed for up-regulation in miR-21 expression in glioblastomas (p |
||
Keywords: microRNA; MGMT methylation; glioblastoma; chemoradiotherapy; temozolomide; | ||
Year: 2010, Volume: 57, Issue: 3 | Page From: 264, Page To: 269 | |
doi:10.4149/neo_2010_03_264 |
||
|
download file |
|